Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model

Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model

Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognitive deficits in the mouse model for this disorder, the Fragile X Mental Retardation 1 (Fmr1) knockout (KO) mouse, have been restored by different pharmacological approaches, among those the blockade o...

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Bibliographic Details
Main Authors: Maria Gomis-González, Arnau Busquets-Garcia, Carlos Matute, Rafael Maldonado, Susana Mato, Andrés Ozaita
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Genes
Subjects:
fragile X syndrome
synaptic plasticity
long-term depression
memory
treatment
cannabinoid receptor
CB1
endocannabinoid system
Online Access:http://www.mdpi.com/2073-4425/7/9/56

Internet

http://www.mdpi.com/2073-4425/7/9/56

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