Phyla- and subtype-selectivity of CgNa, a Na+ channel toxin from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea

Phyla- and subtype-selectivity of CgNa, a Na+ channel toxin from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea

Because of their prominent role in electro-excitability, voltage-gated sodium (NaV) channels have become the foremost important target of animal toxins. These toxins have developed the ability to discriminate between closely related NaV subtypes, making them powerful tools to study NaV channel funct...

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Bibliographic Details
Main Authors: Bert eBillen, Sarah eDebaveye, Lászlo eBéress, Anoland eGarateix, Jan eTytgat
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-11-01
Series:Frontiers in Pharmacology
Subjects:
Selectivity
Sodium channel
Inactivation
toxin
sea anemone
subtype
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00133/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00133/full

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