Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

Abstract Background Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patien...

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Bibliographic Details
Main Authors: Zhengdong Jiang, Cancan Zhou, Liang Cheng, Bin Yan, Ke Chen, Xin Chen, Liang Zong, Jianjun Lei, Wanxing Duan, Qinhong Xu, Xuqi Li, Zheng Wang, Qingyong Ma, Jiguang Ma
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
YAP
Pancreatic cancer
Pancreatic stellate cells
Invasion
Online Access:http://link.springer.com/article/10.1186/s13046-018-0740-4

Internet

http://link.springer.com/article/10.1186/s13046-018-0740-4

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