Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Abstract Background Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro mo...

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Bibliographic Details
Main Authors: Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. Wadsworth, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins, Alex K. Shalek, Jeffrey M. Karp
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Biology
Subjects:
Single-cell RNA-seq
Chemical biology
Stem cell-derived models
Paneth cell
Intestinal organoid
Intestinal stem cell
Online Access:http://link.springer.com/article/10.1186/s12915-018-0527-2

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http://link.springer.com/article/10.1186/s12915-018-0527-2

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