Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.

Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.

The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent, characterized by drug tolerance and little or no bacterial replication. Low oxygen tension is a major host factor inducing bacteriostasis, but the molecular mechanisms driving oxygen-dependent replication are poorly u...

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Bibliographic Details
Main Authors: Corrie Ortega, Reiling Liao, Lindsey N Anderson, Tige Rustad, Anja R Ollodart, Aaron T Wright, David R Sherman, Christoph Grundner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3883633?pdf=render

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http://europepmc.org/articles/PMC3883633?pdf=render

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