Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin

Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin

The excessive release of heme during hemolysis contributes to the severity of sickle cell anemia (SCA) by exacerbating hemoglobin S (HbS) autoxidation, inflammation and systemic tissue damage. The present study investigated the effect of hydroxyurea (HU) on free radical neutralization and its stimul...

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Bibliographic Details
Main Authors: Sânzio Silva Santana, Thassila Nogueira Pitanga, Jeanne Machado de Santana, Dalila Lucíola Zanette, Jamile de Jesus Vieira, Sètondji Cocou Modeste Alexandre Yahouédéhou, Corynne Stéphanie Ahouefa Adanho, Sayonara de Melo Viana, Nivea Farias Luz, Valeria Matos Borges, Marilda Souza Goncalves
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
sickle cell anemia
hydroxyurea
hemin
antioxidant response
Nrf2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01488/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01488/full

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