A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

Abstract Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results in the pathogenesis of neurological and psych...

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Bibliographic Details
Main Authors: Blaise M. Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N. Bledsoe, Bryanna N. Vacca, Tullia V. Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G. Klein
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Pharmacology Research & Perspectives
Subjects:
anti‐NMDA receptor encephalopathy
biased allosteric modulator (BAM)
NMDA receptor
schizophrenia
Online Access:https://doi.org/10.1002/prp2.859

Internet

https://doi.org/10.1002/prp2.859

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