Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

Abstract The specific amyloid-beta (Aβ) species or other amyloid-precursor protein cleavage products that are most directly related to human neurodegeneration and clinical dementia of the Alzheimer’s type have not yet been directly identified. Without a clear understanding of the most relevant speci...

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Bibliographic Details
Main Authors: David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Dementia
Amyloid-beta
Oligomer
Plaque
Neurotoxicity
Online Access:http://link.springer.com/article/10.1186/s13195-017-0293-3

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http://link.springer.com/article/10.1186/s13195-017-0293-3

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