Mechanism of Growth Inhibition of Human Cancer Cells by Conjugated Eicosapentaenoic Acid, an Inhibitor of DNA Polymerase and Topoisomerase

Mechanism of Growth Inhibition of Human Cancer Cells by Conjugated Eicosapentaenoic Acid, an Inhibitor of DNA Polymerase and Topoisomerase

DNA topoisomerases (topos) and DNA polymerases (pols) are involved in manyaspects of DNA metabolism such as replication reactions. We found that long chainunsaturated fatty acids such as polyunsaturated fatty acids (PUFA) (i.e., eicosapentaenoicacid (EPA) and docosahexaenoic acid (DHA)) inhibited th...

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Bibliographic Details
Main Authors: Yoshiyuki Mizushina, Hiromi Yoshida, Yuko Yonezawa
Format: Article
Language:English
Published: MDPI AG 2007-12-01
Series:International Journal of Molecular Sciences
Subjects:
conjugated eicosapentaenoic acid (cEPA)
DNA polymerase
DNA topoisomerase
enzyme inhibitor
DNA replication
cell proliferation
cell cycle arrest
p53
apoptosis
Online Access:http://www.mdpi.com/1422-0067/8/12/1206/

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http://www.mdpi.com/1422-0067/8/12/1206/

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