Systems Perturbation Analysis of a Large Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

Systems Perturbation Analysis of a Large Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic tar...

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Bibliographic Details
Main Authors: Bhanwar Lal ePuniya, Laura eAllen, Colleen eHochfelder, Mahbubul eMajumder, Tomáš eHelikar
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Signal Transduction
Cancer
computational modeling
therapeutic targets
in silico perturbation analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2016.00010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fbioe.2016.00010/full

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