HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells

HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells

Abstract Background Adverse drug reactions (ADRs) are a significant problem for HIV patients, with the risk of developing ADRs increasing as the infection progresses to AIDS. However, the pathophysiology underlying ADRs remains unknown. Sulphamethoxazole (SMX) via its active metabolite SMX-hydroxlya...

Full description

Bibliographic Details
Main Authors: Kemi Adeyanju, John R. Bend, Michael J. Rieder, Gregory A. Dekaban
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Virology Journal
Subjects:
HIV
Adverse drug reaction
Sulphamethoxazole
Thiol proteome
Cysteine thiols
Peroxiredoxin
Online Access:http://link.springer.com/article/10.1186/s12985-018-0991-x

Internet

http://link.springer.com/article/10.1186/s12985-018-0991-x

Similar Items