Epigenetic Changes at the <i>Birc5</i> Promoter Induced by YM155 in Synovial Sarcoma

Epigenetic Changes at the <i>Birc5</i> Promoter Induced by YM155 in Synovial Sarcoma

YM155 is an anti-cancer therapy that has advanced into 11 different human clinical trials to treat various cancers. This apoptosis-inducing therapy indirectly affects the protein levels of survivin (gene: <i>Birc5</i>), but the molecular underpinnings of the mechanism remain largely unkn...

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Bibliographic Details
Main Authors: Aleksander Mika, Sarah E. Luelling, Adriene Pavek, Christopher Nartker, Alexandra L. Heyneman, Kevin B. Jones, Jared J. Barrott
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Journal of Clinical Medicine
Subjects:
survivin
<i>Birc5</i>
synovial sarcoma
YM155
epigenetics
Online Access:https://www.mdpi.com/2077-0383/8/3/408

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