Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents

Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents

A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane derivatives 2. Reaction of the epoxide 2 with 2-amino-5-...

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Bibliographic Details
Main Authors: Maher A. El-Hashash, Sameh A. Rizk, Saad R. Atta-Allah
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
4-aryl-4-oxo-but-2-enoic acid
oxirane
chalcone
imidazo[2,1-b]thiadiazole
spiropyrazole
spiroisoxazole
spiropyrane
Online Access:http://www.mdpi.com/1420-3049/20/12/19827

Internet

http://www.mdpi.com/1420-3049/20/12/19827

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