Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic

Abstract The PspC and Hic proteins of Streptococcus pneumoniae are some of the most variable microbial immune evasion proteins identified to date. Due to structural similarities and conserved binding profiles, it was assumed for a long time that these pneumococcal surface proteins represent a protei...

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Bibliographic Details
Main Authors: Shanshan Du, Cláudia Vilhena, Samantha King, Alfredo Sahagún-Ruiz, Sven Hammerschmidt, Christine Skerka, Peter F. Zipfel
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79362-3