NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood. We show here that chemical activation of NRF2 modifies circadian gene expression and rhythmicity, with phenotypes similar to genetic NR...

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Bibliographic Details
Main Authors: Ryan S Wible, Chidambaram Ramanathan, Carrie Hayes Sutter, Kristin M Olesen, Thomas W Kensler, Andrew C Liu, Thomas R Sutter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
circadian rhythm
Nrf2
Redox
Online Access:https://elifesciences.org/articles/31656

Internet

https://elifesciences.org/articles/31656

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