Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model

Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model

Summary: The tumor microenvironment (TME) polarizes tumor-infiltrating macrophages toward tumor support. Macrophage-abundant tumors are highly malignant and are the cause of poor prognosis and therapeutic resistance. In this study, we show that the prolyl hydroxylase (PHD) inhibitor FG-4592 (FG) inh...

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Bibliographic Details
Main Authors: Shunji Nishide, Shinji Matsunaga, Masayuki Shiota, Takehiro Yamaguchi, Shojiro Kitajima, Yoichi Maekawa, Norihiko Takeda, Michio Tomura, Junji Uchida, Katsuyuki Miura, Tatsuya Nakatani, Shuhei Tomita
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219303116

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http://www.sciencedirect.com/science/article/pii/S2589004219303116

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