The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice

The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice

Trans-differentiation of endothelial cells to myofibroblast contributes to liver fibrosis. Reactive oxygen species (ROS) plays a key role in endothelial-mesenchymal transition (EndMT) although the underlying epigenetic mechanism is unclear. Here we report that endothelial conditional knockout of Brg...

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Bibliographic Details
Main Authors: Zilong Li, Baoyu Chen, Wenhui Dong, Ming Kong, Yang Shao, Zhiwen Fan, Liming Yu, Dongmei Wu, Jun Lu, Junli Guo, Yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EndMT
ROS
liver fibrosis
transcriptional regulation
epigenetics
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00245/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00245/full

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