Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis

Why ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased pre...

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Bibliographic Details
Main Authors: Xiaoxiao Lu, Abirami Kugadas, Kirsten Smith-Page, Jeffrey Lamb, Tiffany Lin, Yusha Ru, Sharon Celeste Morley, Raina Fichorova, Sharad K. Mittal, Sunil K. Chauhan, Sejiro Littleton, Daniel Saban, Mihaela Gadjeva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
commensals
neutrophils
keratritis
P. aeruginosa
macrophages
infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00547/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00547/full

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