Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage

Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage

Pluripotent stem cells (PSCs) maintain a low mutation frequency compared with somatic cell types at least in part by preferentially utilizing error-free homologous recombination (HR) for DNA repair. Many endogenous metabolites cause DNA interstrand crosslinks, which are repaired by the Fanconi anemi...

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Bibliographic Details
Main Authors: Timothy M. Chlon, Sonya Ruiz-Torres, Logan Maag, Christopher N. Mayhew, Kathryn A. Wikenheiser-Brokamp, Stella M. Davies, Parinda Mehta, Kasiani C. Myers, James M. Wells, Susanne I. Wells
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003665

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http://www.sciencedirect.com/science/article/pii/S2213671115003665

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