Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth, but in most cancers it is overexpressed and associated with treatment-resistance and lethal outcomes. Over 40 years o...

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Bibliographic Details
Main Authors: Lavinia A. Carabet, Paul S. Rennie, Artem Cherkasov
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
Myc-Max
cancer
therapeutic strategies
computer-aided drug discovery
small-molecule inhibitors
protein–protein interactions
protein-DNA interactions
Online Access:http://www.mdpi.com/1422-0067/20/1/120

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http://www.mdpi.com/1422-0067/20/1/120

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