Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and showed that expression was modulated...

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Bibliographic Details
Main Authors: Mathew Van de Pette, Allifia Abbas, Amelie Feytout, Gráinne McNamara, Ludovica Bruno, Wilson K. To, Andrew Dimond, Alessandro Sardini, Zoe Webster, James McGinty, Eleanor J. Paul, Mark A. Ungless, Paul M.W. French, Dominic J. Withers, Anthony Uren, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Amanda G. Fisher
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
imprinting
Cdkn1c
environmental stress
bioluminescence
luciferase reporter mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300281

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http://www.sciencedirect.com/science/article/pii/S2211124717300281

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