UPF1/SMG7-dependent microRNA-mediated gene regulation

UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent regulation.

Bibliographic Details
Main Authors: Jungyun Park, Jwa-Won Seo, Narae Ahn, Seokju Park, Jungwook Hwang, Jin-Wu Nam
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12123-7