Engineered Biosynthesis of Alkyne-Tagged Polyketides by Type I PKSs

Summary: Polyketides produced by modular polyketide synthases (PKSs) are important small molecules widely used as drugs, pesticides, and biological probes. Tagging these polyketides with a clickable functionality enables the visualization, diversification, and mode of action study through bio-orthog...

Full description

Bibliographic Details
Main Authors: William B. Porterfield, Nannalin Poenateetai, Wenjun Zhang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030122X