Empirical Evaluation of the Use of Computational HLA Binding as an Early Filter to the Mass Spectrometry-Based Epitope Discovery Workflow

Empirical Evaluation of the Use of Computational HLA Binding as an Early Filter to the Mass Spectrometry-Based Epitope Discovery Workflow

Immunopeptidomics is used to identify novel epitopes for (therapeutic) vaccination strategies in cancer and infectious disease. Various false discovery rates (FDRs) are applied in the field when converting liquid chromatography-tandem mass spectrometry (LC-MS/MS) spectra to peptides. Subsequently, l...

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Bibliographic Details
Main Authors: Rachid Bouzid, Monique T. A. de Beijer, Robbie J. Luijten, Karel Bezstarosti, Amy L. Kessler, Marco J. Bruno, Maikel P. Peppelenbosch, Jeroen A. A. Demmers, Sonja I. Buschow
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
cancer
immunopeptidomics
antigen presentation
HLA-peptide
Online Access:https://www.mdpi.com/2072-6694/13/10/2307

Internet

https://www.mdpi.com/2072-6694/13/10/2307

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