Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs).

MicroRNAs (miRNAs) have quickly emerged as important regulators of mammalian physiology owing to their precise control over the expression of critical protein coding genes. Despite significant progress in our understanding of how miRNAs function in mice, there remains a fundamental need to be able t...

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Bibliographic Details
Main Authors: Ruozhen Hu, Jared Wallace, Timothy J Dahlem, David Jonah Grunwald, Ryan M O'Connell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3646762?pdf=render