Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

Abstract Background Several genetic alterations, including point mutations and copy number variations in NLGN genes, have been associated with psychiatric disorders, such as autism spectrum disorder (ASD) and X-linked mental retardation (XLMR). NLGN genes encode neuroligin (NL) proteins, which are a...

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Bibliographic Details
Main Authors: Takafumi Yumoto, Misaki Kimura, Ryota Nagatomo, Tsukika Sato, Shun Utsunomiya, Natsue Aoki, Motoji Kitaura, Koji Takahashi, Hiroshi Takemoto, Hirotaka Watanabe, Hideyuki Okano, Fumiaki Yoshida, Yosuke Nao, Taisuke Tomita
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Autism
Subjects:
Neuroligin 4X
Proteolysis
Trafficking
Synaptogenesis
Online Access:http://link.springer.com/article/10.1186/s13229-020-00373-y

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http://link.springer.com/article/10.1186/s13229-020-00373-y

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