Galpha<sub>s</sub>-coupled receptor signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: A possible mechanism for cell de-adhesion

Galpha<sub>s</sub>-coupled receptor signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: A possible mechanism for cell de-adhesion

<p>Abstract</p> <p>Background</p> <p>Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (...

Full description

Bibliographic Details
Main Authors:	Amit Or, Waller Anna, Chigaev Alexandre, Sklar Larry A
Format:	Article
Language:	English
Published:	BMC 2008-06-01
Series:	BMC Immunology
Online Access:	http://www.biomedcentral.com/1471-2172/9/26

Similar Items

Nitric oxide/cGMP pathway signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
by: Sklar Larry A, et al.
Published: (2011-05-01)

TGFβ<sub>1 </sub>signaling via α<sub>V</sub>β<sub>6 </sub>integrin
by: Sclabas Guido M, et al.
Published: (2003-08-01)

α<sub>4</sub>β<sub>1</sub> and α<sub>M</sub>β<sub>2</sub> Integrin Expression and Pro-Proliferative Properties of Eosinophil Subtypes in Asthma
by: Egle Jurkeviciute, et al.
Published: (2021-08-01)

Differential Expression of Integrin α<sub>3</sub>β<sub>1</sub> and α<sub>6</sub>β<sub>4</sub> Molecules on a Panel of Rat Esophageal Cell Lines
by: Chakraborty, Arup Ratan
Published: (2005)

A selective cyclic integrin antagonist blocks the integrin receptors α<sub>v</sub>β<sub>3 </sub>and α<sub>v</sub>β<sub>5 </sub>and inhibits retinal pigment epithelium cell attachment, migration and invasion
by: Wiedemann Peter, et al.
Published: (2005-06-01)

TGFβ<sub>1 </sub>activates c-Jun and Erk1 via α<sub>V</sub>β<sub>6 </sub>integrin
by: Schmidt Christian, et al.
Published: (2003-09-01)

Retraction: TGFβ<sub>1 </sub>signaling via a<sub>V</sub>β<sub>6 </sub>integrin
by: Sclabas Guido M, et al.
Published: (2004-01-01)

A Single-Nucleotide Polymorphism of α<sub>V</sub>β<sub>3</sub> Integrin Is Associated with the Andes Virus Infection Susceptibility
by: Constanza Martínez-Valdebenito, et al.
Published: (2019-02-01)

Evaluation of the anti-angiogenic properties of the new selective α<sub>V</sub>β<sub>3 </sub>integrin antagonist RGDechiHCit
by: Trimarco Bruno, et al.
Published: (2011-01-01)

Targeting α<sub>ν</sub>β<sub>3 </sub>and α<sub>ν</sub>β<sub>5 </sub>inhibits photon-induced hypermigration of malignant glioma cells
by: Weber Klaus, et al.
Published: (2011-10-01)

Retraction: TGFβ<sub>1 </sub>activates c-Jun and Erk1 via a<sub>V</sub>β<sub>6 </sub>integrin
by: Schmidt Christian, et al.
Published: (2004-01-01)

Comparison of Linear vs. Cyclic RGD Pentapeptide Interactions with Integrin α<sub>v</sub>β<sub>3</sub> by Molecular Dynamics Simulations
by: Na Li, et al.
Published: (2021-07-01)

Heterogeneity of Integrin α<sub>IIb</sub>β<sub>3</sub> Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis
by: Alexey A. Martyanov, et al.
Published: (2020-04-01)

Functional blockade of α<sub>5</sub>β<sub>1 </sub>integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells
by: Lorenti Alicia, et al.
Published: (2010-10-01)

Towards Macroporous α-Al<sub>2</sub>O<sub>3</sub>—Routes, Possibilities and Limitations
by: Simon Carstens, et al.
Published: (2020-04-01)

Comparative Study on Electronic Structure and Optical Properties of α-Fe<sub>2</sub>O<sub>3</sub>, Ag/α-Fe<sub>2</sub>O<sub>3</sub> and S/α-Fe<sub>2</sub>O<sub>3</sub>
by: Cuihua Zhao, et al.
Published: (2021-03-01)

Structure and magnetism of nanocrystalline exchange-coupled (Ni<sub>0</sub>.<sub>6</sub><sub>7</sub>Co<sub>0</sub>.<sub>2</sub><sub>5</sub>Fe<sub>0</sub>.<sub>0</sub><sub>8</sub>)<sub>8</sub><sub>9</sub><sub>-</sub><sub>x</sub>Zr<sub>7</sub>B<sub>4</sub>Cu<sub>x</sub> (x=0,1) films
Published: ()

<it>In vivo </it>optical imaging of integrin α<sub>V</sub>-β<sub>3 </sub>in mice using multivalent or monovalent cRGD targeting vectors
by: Boturyn Didier, et al.
Published: (2007-06-01)

The Antithrombotic Agent Pterostilbene Interferes with Integrin α<sub>IIb</sub>β<sub>3</sub>-Mediated Inside-Out and Outside-In Signals in Human Platelets
by: Wei-Chieh Huang, et al.
Published: (2021-03-01)

PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin α<sub>v</sub>β<sub>3</sub> Receptors
by: Christos Liolios, et al.
Published: (2021-03-01)

Interactions via α<sub>2</sub>β<sub>1</sub> Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma
by: Stanislawa Bazan-Socha, et al.
Published: (2021-06-01)

Spin-spray deposited multiferroic composite Ni<sub>0</sub>.<sub>2</sub><sub>3</sub>Fe<sub>2</sub>.<sub>7</sub><sub>7</sub>O<sub>4</sub>/Pb(Zr,Ti)O<sub>3</sub> with strong interface adhesion
Published: ()

Optimization of α-Fe<sub>2</sub>O<sub>3</sub> Nanopillars Diameters for Photoelectrochemical Enhancement of α-Fe<sub>2</sub>O<sub>3</sub>-TiO<sub>2</sub> Heterojunction
by: Herme G. Baldovi
Published: (2021-08-01)

Diode laser-based cavity ring-down instrument for NO<sub>3</sub>, N<sub>2</sub>O<sub>5</sub>, NO, NO<sub>2</sub> and O<sub>3</sub> from aircraft
by: T. B. Ryerson, et al.
Published: (2011-06-01)

Investigation of the Production of β-Al<sub>2</sub>O<sub>3</sub> Solid Electrolyte from Seydişehir α-Al<sub>2</sub>O<sub>3</sub>
by: Selin ENGÜRLÜ, et al.
Published: (2017-10-01)

Interleukin-1α enhances the aggressive behavior of pancreatic cancer cells by regulating the α<sub>6</sub>β<sub>1</sub>-integrin and urokinase plasminogen activator receptor expression
by: Takeyama Hiromitsu, et al.
Published: (2006-02-01)

BaFe<sub>1</sub><sub>2</sub>O<sub>1</sub><sub>9</sub> thin films grown at the atomic scale from BaFe<sub>2</sub>O<sub>4</sub> and α-Fe<sub>2</sub>O<sub>3</sub> targets
Published: ()

Pulsed laser ablation deposition of nanocrystalline exchange-coupled Ni<sub>1</sub><sub>1</sub>Co<sub>1</sub><sub>1</sub>Fe<sub>6</sub><sub>7</sub><sub>-</sub><sub>x</sub>Zr<sub>7</sub>B<sub>4</sub>Cux (x=0,1) films for planar inductor applications
Published: ()

Microwave, magnetic, and structural properties of nanocrystalline exchange-coupled Ni<sub>1</sub><sub>1</sub>Co<sub>1</sub><sub>1</sub>Fe<sub>6</sub><sub>6</sub>Zr<sub>7</sub>B<sub>4</sub>Cu<sub>1</sub> films for high frequency applications
Published: ()

Suppression of Human Platelet Activation via Integrin α<sub>IIb</sub>β<sub>3</sub> Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene
by: Chih-Wei Hsia, et al.
Published: (2019-11-01)

Efficacy of a Selective Binder of α<sub>V</sub>β<sub>3</sub> Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models
by: Andrea Sartori, et al.
Published: (2019-04-01)

Electric Double Layer Doping of Charge-Ordered Insulators α-(BEDT-TTF)<sub>2</sub>I<sub>3</sub> and α-(BETS)<sub>2</sub>I<sub>3</sub>
by: Yoshitaka Kawasugi, et al.
Published: (2021-07-01)

Electron-spin-resonance in single-crystals of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7</sub><sub>-</sub><sub>x</sub> and Bi<sub>4</sub>/<sub>3</sub>Pb<sub>2</sub>/<sub>3</sub>Sr<sub>2</sub>CaCu<sub>2</sub>O<sub>8</sub><sub>+</sub><sub>x</sub>
Published: ()

Superparamagnetic α-Fe<sub>2</sub>O<sub>3</sub>/Fe<sub>3</sub>O<sub>4</sub> Heterogeneous Nanoparticles with Enhanced Biocompatibility
by: You Li, et al.
Published: (2021-03-01)

Evaluation of High-Temperature Hydrogen Sensors Based on BaCe<sub>0.6</sub>Zr<sub>0.3</sub>Y<sub>0.1</sub>O<sub>3-α</sub> and Sr(Ce<sub>0.9</sub>Zr<sub>0.1</sub>)<sub>0.95</sub>Yb<sub>0.05</sub>O<sub>3-α</sub> Perovskites for Industrial Applications
by: Antonio Hinojo, et al.
Published: (2020-12-01)

A two-channel thermal dissociation cavity ring-down spectrometer for the detection of ambient NO<sub>2</sub>, RO<sub>2</sub>NO<sub>2</sub> and RONO<sub>2</sub>
by: J. Thieser, et al.
Published: (2016-02-01)

Nanosheet-Like Ho<sub>2</sub>O<sub>3</sub> and Sr-Ho<sub>2</sub>O<sub>3</sub> Catalysts for Oxidative Coupling of Methane
by: Yuqiao Fan, et al.
Published: (2021-03-01)

Oxidative Coupling of Methane over Mn<sub>2</sub>O<sub>3</sub>-Na<sub>2</sub>WO<sub>4</sub>/SiC Catalysts
by: Jieun Kim, et al.
Published: (2019-04-01)

Propiedades ópticas del pigmento α-Fe<sub>2</sub>O<sub>3</sub>/SiO<sub>2</sub>
by: Chicariano, C. A., et al.
Published: (2005-08-01)

Indium Ammoniates from Ammonothermal Synthesis: InAlF<sub>6</sub>(NH<sub>3</sub>)<sub>2</sub>, [In(NH<sub>3</sub>)<sub>6</sub>][AlF<sub>6</sub>], and [In<sub>2</sub>F(NH<sub>3</sub>)<sub>10</sub>]<sub>2</sub>[SiF<sub>6</sub>]<sub>5</sub> ∙ 2 NH<sub>3</sub>
by: Peter Becker, et al.
Published: (2021-06-01)