Galpha<sub>s</sub>-coupled receptor signaling actively down-regulates α<sub>4</sub>β<sub>1</sub>-integrin affinity: A possible mechanism for cell de-adhesion
<p>Abstract</p> <p>Background</p> <p>Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-06-01
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| Series: | BMC Immunology |
| Online Access: | http://www.biomedcentral.com/1471-2172/9/26 |