SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

The transcription factor SOX2 is central in establishing and maintaining pluripotency. The processes that modulate SOX2 activity to promote pluripotency are not well understood. Here, we show SOX2 is O-GlcNAc modified in its transactivation domain during reprogramming and in mouse embryonic stem cel...

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Bibliographic Details
Main Authors: Samuel A Myers, Sailaja Peddada, Nilanjana Chatterjee, Tara Friedrich, Kiichrio Tomoda, Gregor Krings, Sean Thomas, Jason Maynard, Michael Broeker, Matthew Thomson, Katherine Pollard, Shinya Yamanaka, Alma L Burlingame, Barbara Panning
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
SOX2
O-GlcNAc
pluripotency
transcription factors
embryonic stem cells
electron transfer dissociation
Online Access:https://elifesciences.org/articles/10647

Internet

https://elifesciences.org/articles/10647

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