DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors

DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors

BackgroundDNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel the implications of DDR pathways in the shaping of immune responsiveness in colorectal cancer (CRC) patients receiving immune checkpoint inhibitors (ICI).Methods...

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Bibliographic Details
Main Authors: Yipeng Song, Jian Huang, Dandan Liang, Ying Hu, Beibei Mao, Qiujing Li, Huaibo Sun, Ying Yang, Jiao Zhang, Henghui Zhang, Huan Chen, Hao Liu, Shukun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
DNA damage repair (DDR)
immune checkpoint inhibitor (ICI)
colorectal cancer (CRC)
biomarker
microsatellite instability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.549777/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.549777/full

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