5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis

5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis

Leukotrienes (LTs) constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate and colorectal carcinogenesis. First, several independent studi...

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Bibliographic Details
Main Authors: Dieter eSteinhilber, Astrid Stefanie Fischer, Julia eMetzner, Svenja Dorothea Steinbrink, Jessica eRoos, Martin eRuthardt, Thorsten Jürgen Maier
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-12-01
Series:Frontiers in Pharmacology
Subjects:
Apoptosis
Cell Proliferation
off-target effect
Cytotoxicity
Pancreatic Cancer
leukotriene
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00143/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00143/full

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