A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

High genetic and phenotypic variability between <i>Leishmania</i> species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse <i>Leishmania</i> species can be useful in enabl...

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Bibliographic Details
Main Authors: Laura M. Alcântara, Thalita C. S. Ferreira, Vanessa Fontana, Eric Chatelain, Carolina B. Moraes, Lucio H. Freitas-Junior
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
<i>Leishmania</i>
leishmaniasis drug discovery
phenotypic screening
<i>Leishmania</i> species
Online Access:https://www.mdpi.com/1420-3049/25/11/2551

Internet

https://www.mdpi.com/1420-3049/25/11/2551

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