Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking

Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking

Abstract T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, result...

Full description

Bibliographic Details
Main Authors: Ye Zhang, Hao Shen, Haifeng Liu, Haiyun Feng, Yan Liu, Xiaoyan Zhu, Xiaolong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08357-4

Internet

https://doi.org/10.1038/s41598-017-08357-4

Similar Items