IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB kinase family member IKK-ε is essential in regulat...

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Bibliographic Details
Main Authors: Anna Lisa Remoli, Marco Sgarbanti, Edvige Perrotti, Marta Acchioni, Roberto Orsatti, Chiara Acchioni, Angela Battistini, Robert Clarke, Giulia Marsili
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
IKK-ε
IRF-1
breast cancer
phosphorylation
K48 polyubiquitination
protein stability
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301354

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http://www.sciencedirect.com/science/article/pii/S1476558620301354

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