Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease

L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease. An increasing body of evidence points to the serotonin system as a key player in the appearance of L-DOPA-induced dyskinesia...

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Bibliographic Details
Main Authors: Eunju Shin, Elisabetta Tronci, Manolo Carta
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2012/370190