Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen

Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen

A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vect...

Full description

Bibliographic Details
Main Authors: Stanislav A. Petrov, Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay Y. Zyk, Ekaterina A. Nimenko, Anastasia S. Garanina, Rostislav A. Petrov, Vladimir I. Polshakov, Yuri K. Grishin, Vitaly A. Roznyatovsky, Nikolay V. Zyk, Alexander G. Majouga, Elena K. Beloglazkina
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
theranostic agent
peptide synthesis
prostate cancer
anticancer drugs
PSMA conjugate
docetaxel
Online Access:https://www.mdpi.com/1420-3049/25/24/5784

Internet

https://www.mdpi.com/1420-3049/25/24/5784

Similar Items