PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

NORAD is a conserved long noncoding RNA (lncRNA) that is required for genome stability in mammals. NORAD acts as a negative regulator of PUMILIO (PUM) proteins in the cytoplasm, and we previously showed that loss of NORAD or PUM hyperactivity results in genome instability and premature aging in mice...

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Bibliographic Details
Main Authors: Mahmoud M Elguindy, Florian Kopp, Mohammad Goodarzi, Frederick Rehfeld, Anu Thomas, Tsung-Cheng Chang, Joshua T Mendell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
NORAD
PUMILIO
RBMX
long noncoding RNA
genome stability
lncRNA
Online Access:https://elifesciences.org/articles/48625

Internet

https://elifesciences.org/articles/48625

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