Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.

Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.

RATIONALE: Inflammatory mechanisms have been suggested to play a role in the development of heart failure (HF), but a role for chemokines is largely unknown. Based on their role in inflammation and matrix remodeling in other tissues, we hypothesized that CXCL13 and CXCR5 could be involved in cardiac...

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Bibliographic Details
Main Authors: Anne Waehre, Bente Halvorsen, Arne Yndestad, Cathrine Husberg, Ivar Sjaastad, Ståle Nygård, Christen P Dahl, M Shakil Ahmed, Alexandra V Finsen, Henrik Reims, William E Louch, Denise Hilfiker-Kleiner, Leif E Vinge, Borghild Roald, Håvard Attramadal, Martin Lipp, Lars Gullestad, Pål Aukrust, Geir Christensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3078912?pdf=render

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http://europepmc.org/articles/PMC3078912?pdf=render

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