Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation

Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation

Ligand-gated ion channels couple the free energy of agonist binding to the gating of selective transmembrane ion pores, permitting cells to regulate ion flux in response to external chemical stimuli. However, the stereochemical mechanisms responsible for this coupling remain obscure. In the case of...

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Bibliographic Details
Main Authors: Charles R. Midgett, Avinash eGill, Dean R. Madden
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Ligand-Gated Ion Channels
Electron microscopy
Ionotropic glutamate receptors
protein structure
receptor activation
single-particle reconstruction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00056/full

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