Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.

Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.

Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis. Transgenic mice expressing CD154 by their B cells (CD154(TG)) have an expanded spleen B cell pool and produ...

Full description

Bibliographic Details
Main Authors: Jonathan C Poe, Susan H Smith, Karen M Haas, Koichi Yanaba, Takeshi Tsubata, Takashi Matsushita, Thomas F Tedder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143148?pdf=render

Internet

http://europepmc.org/articles/PMC3143148?pdf=render

Similar Items