Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker

Abstract The tryptophan to kynurenine ratio (Trp/Kyn) has been proposed as a cancer biomarker. Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics. By performing in vitro pig skin permeability studies, we conclude that non-invasive topical...

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Bibliographic Details
Main Authors: Skaidre Jankovskaja, Johan Engblom, Melinda Rezeli, György Marko-Varga, Tautgirdas Ruzgas, Sebastian Björklund
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79903-w