Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons. Here, we demonstrate that inactivation of apoptosis-inducing factor (AIF) in POMC neurons mildly impairs mitochondrial r...

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Bibliographic Details
Main Authors: Katharina Timper, Lars Paeger, Carmen Sánchez-Lasheras, Luis Varela, Alexander Jais, Hendrik Nolte, Merly C. Vogt, A. Christine Hausen, Christian Heilinger, Nadine Evers, J. Andrew Pospisilik, Josef M. Penninger, Eric B. Taylor, Tamas L. Horvath, Peter Kloppenburg, Jens Claus Brüning
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314797

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http://www.sciencedirect.com/science/article/pii/S2211124718314797

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