IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses.

IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses.

A rare subset of IL-10-producing B cells, named regulatory B cells (Bregs), suppresses adaptive immune responses and inflammation in mice. In this study, we examined the role of IL-10-producing B cells in HIV-1 infection. Compared to uninfected controls, IL-10-producing B cell frequencies were eleva...

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Bibliographic Details
Main Authors: Jun Liu, Wei Zhan, Connie J Kim, Kiera Clayton, Hanqi Zhao, Erika Lee, Jin Chao Cao, Blake Ziegler, Alexander Gregor, Feng Yun Yue, Sanja Huibner, Sonya MacParland, Jordan Schwartz, Hai Han Song, Erika Benko, Gabor Gyenes, Colin Kovacs, Rupert Kaul, Mario Ostrowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3931714?pdf=render

Internet

http://europepmc.org/articles/PMC3931714?pdf=render

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