Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...

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Bibliographic Details
Main Authors: Yue Zhang, Jianliang Geng, Yu Hong, Li Jiao, Shuning Li, Runbin Sun, Yuan Xie, Caixia Yan, Jiye Aa, Guangji Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
crocin
cerebral ischemia-reperfusion
drug metabolism
gut microbiota
metabolomics
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00440/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00440/full

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