Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System

Although it has long been known that S. aureus forms triacylated Lpps, a lack of homologs to known N-acylation genes found in Gram-negative bacteria has until now precluded identification of the genes responsible for this Lpp modification. Here, we demonstrate N-terminal Lpp acylation and chemotype...

Full description

Bibliographic Details
Main Authors: John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith
Format: Article
Language:English
Published: American Society for Microbiology 2020-07-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.01619-20