Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

<p>Abstract</p> <p>Background</p> <p>Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate de...

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Bibliographic Details
Main Authors: Riker Adam I, Fodstad Oystein, Liu Zixing, Liu Hao, Ding Yan, Zhao Yuhua, Zhou Ming, Kamarajugadda Sushama, Lu Jianrong, Owen Laurie B, Ledoux Susan P, Tan Ming
Format: Article
Language:English
Published: BMC 2010-02-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/33