Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

Abstract IL-2 is the master-regulator cytokine for T cell dependent responses and is crucial for proliferation and survival of T cells. However, IL-2-based treatments remained marginal, in part due to short half-life. Thus, we aimed to extend IL-2 half-life by flanking the IL-2 core with sequences d...

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Bibliographic Details
Main Authors: Aner Ottolenghi, Priyanka Bolel, Rhitajit Sarkar, Yariv Greenshpan, Muhammed Iraqi, Susmita Ghosh, Baisali Bhattacharya, Zoe V. Taylor, Kiran Kundu, Olga Radinsky, Roi Gazit, David Stepensky, Ron N. Apte, Elena Voronov, Angel Porgador
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87102-4

Internet

https://doi.org/10.1038/s41598-021-87102-4

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