Leishmania specific CD4 T cells release IFNγ that limits parasite replication in patients with visceral leishmaniasis.

Leishmania specific CD4 T cells release IFNγ that limits parasite replication in patients with visceral leishmaniasis.

Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFNγ, and TNFα, and elevated expression of IFNγ mRNA in lesional tissue such as the spleen and bone marrow. However, an immunological feature of VL pati...

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Bibliographic Details
Main Authors: Rajiv Kumar, Neetu Singh, Shalini Gautam, Om Prakash Singh, Kamlesh Gidwani, Madhukar Rai, David Sacks, Shyam Sundar, Susanne Nylén
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4183461?pdf=render

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http://europepmc.org/articles/PMC4183461?pdf=render

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