Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

The retinal pigment epithelium (RPE) forms the outer blood⁻retina barrier and facilitates the transepithelial transport of glucose into the outer retina via GLUT1. Glucose is metabolized in photoreceptors via the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) but als...

Full description

Bibliographic Details
Main Authors: Thierry Léveillard, Nancy J. Philp, Florian Sennlaub
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
cone photoreceptor
inflammatory macrophage
aerobic glycolysis
lactate transporter
retinal degeneration
rod-derived cone viability factor
Online Access:https://www.mdpi.com/1422-0067/20/3/762

Internet

https://www.mdpi.com/1422-0067/20/3/762

Similar Items