β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

β-Mangostin (βM) was isolated from Cratoxylum arborescens to investigate its anti-cancer effect in MCF-7 cells. βM induced apoptosis by down-regulation of Bcl2 and up-regulation of Bax, triggering the cytochrome c release from mitochondria to cytosol. The release of caspase-9 and -7 and consequently...

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Bibliographic Details
Main Authors: Suvitha Syam, Ahmad Bustamam, Rasedee Abdullah, Mohamed Aspollah Sukari, Najihah Mohd Hashim, Mostafa Ghaderian, Mawardi Rahmani, Syam Mohan, Siddig Ibrahim Abdelwahab, Hapipah Mohd Ali
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Functional Foods
Subjects:
Cratoxylum arborescens
β-Mangostin
Apoptosis
p53
NF-kB
Bax/Bcl-2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464613002466

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http://www.sciencedirect.com/science/article/pii/S1756464613002466

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